27 Oct RESP 106 Respiratory Pharmacology

Ivy Tech Community College

RESP 106 Respiratory Pharmacology

Homework Number 4

Mucus-controllers, Surfactants, Corticosteroids, & Anti-asthmatic agents

Name: __________________________________ ________ / 22 pts

1. List seven factors that can slow mucociliary transport. 3.5 pts

.

2. What are two indications for the use of N-Acetylcysteine? 2 pts

3. What is the most serious hazard that can occur with the use of N-Acetylcysteine? 2 pts

a. How can the incidence of this hazard occurring be decreased?

4. Pulmozyme is a drug approved for treatment of tenacious sputum in patients with cystic 

fibrosis. How does this drug decrease the tenacity of the sputum? 1 pt

5. Why is hypertonic saline thought to improve mucociliary transport? 1pt

6. The force caused by the attraction between like molecules, which occur at the liquid- gas 

interface, and that holds the liquid surface intact, is called _________________ 

__________________. 1 pt

7. What is the primary function of surfactant in the lungs? 1 pt

8. _______________ surfactants are obtained from animals or humans by alveolar wash or 

from amniotic fluid. 1 pt

9. Survanta and Infasurf come from ___________ lungs, and Curosurf comes from 

_____________ lungs. 1 pt

10. What type of effect do glucocorticoids, also known as steroids, have on the body? 1 pt

11. List six side effects associated with systemic administration of corticosteroids. 3 pts

.

.

12. List three ways to minimize the local side effects of inhaled steroid administration. 1.5 

pts

1. .

2. .

3. .

13. Cromolyn sodium is used as a _______________ agent in order to prevent asthma 

attacks. 1 pt

14. Explain the benefit of asthmatic patients using a drug such as Cromolyn Sodium to 

stabilize the mast cell. 1 pt

15. Name two anti-leukotriene agents that have been approved for use in the United States. 2 

pts

1. .

2.