15 Feb What is the proposed source of the polybasic cleavage site inserted in SARS-CoV-2? closely related “lineage B” betacoronaviruses other betacoronaviruses HIV influenza virus Part
Question #1
only one answer correct per question
Part 1-
What is the proposed source of the polybasic cleavage site inserted in SARS-CoV-2?
closely related “lineage B” betacoronaviruses
other betacoronaviruses
HIV
influenza virus
Part 2-
Based on lab studies with SARS-CoV-2 and and analysis of other viruses, what is the biological significance of the furin cleavage site in the S protein?
increased cell-cell fusion, increased infection of human cells, more efficient spread among hosts
decreased cell-cell fusion, increased infection of human cells, more efficient spread among hosts
increased cell-cell fusion, increased infection of human cells, less efficient spread among hosts
decreased cell-cell fusion, decreased infection of human cells, more efficient spread among hosts
Part 3-
In which animal has the known precursor of SARS-CoV-2 been found?
pangolin
civet cat
ferret
None of the above
Part 4-
Where does the polybasic cleavage site fit into the bat and pangolin S protein sequences?
Both species have the polybasic cleavage site.
Only the bat sequence has the polybasic cleavage site.
Neither animal virus has the polybasic cleavage site.
Part 5-
In the second hypothesis that the virus mutated and adapted to human transmission after jumping from an animal, what animal do the authors propose was the proximal host before humans?
pangolin
ferret
civet cat
None of the above
References:
Title: The proximal origin of SARS-CoV-2
https://www.nature.com/articles/s41591-020-0820-9
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