27 Oct Prevalent mutations and mutation types
Using the cBioPortal for Cancer Genomics (www.cbioportal.org) website, find the prevalent mutations (e.g. G12V) and mutation types (e.g., missense, truncation) in each gene, APC and CTNNB1, using the MSK-IMPACT Clinical Sequencing Cohort dataset containing 10945 tumor samples (PanCancer Studies).
Discuss the functional consequences of each mutation type.
2. What insight does each mutation type provide related to the gene function in cancer (hint: tumor suppressor vs oncogene)? Explain why
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