27 Oct Follicular dendritic cells present antigen to test the antigen-binding domain of B cells that have undergone the process of:

 Follicular dendritic cells present antigen to test the antigen-binding domain of B cells that have undergone the process of:

 

Select one:

 

A.Class-switch recombination

 

 

 

B.Somatic hypermutation

 

 

 

C.Clonal expansion

 

 

 

D.V(D)J recombination

 

 

 

22) There are two isoforms of CD45: CD45RA (which is longer) and CD45RO (which is shorter). The shorter version allows the cell to respond to smaller concentrations of MHC:antigen. Which cell type expresses CD45RO?

 

Select one:

 

A.Naive CD4 T cells

 

 

 

B.Activated CD4 T cells

 

 

 

C.Activated B cells

 

 

 

D.Naive CD8 T cells

 

 

 

26) Immune complexes bound by RBCs (via CR1) are destroyed by what cell type in the liver and spleen?

 

Select one:

 

A.neutrophils

 

 

 

B.macrophages

 

 

 

C.follicular dendritic cells

 

 

 

D.NK cells

 

 

 

28) The absence of CD40L causes what disease?

 

Select one:

 

A.Original antigenic sin

 

 

 

B.Acquired Immunodeficiency Syndrome

 

 

 

C.Hyper IgM Syndrome

 

 

 

D.Leprosy

 

 

 

 

 

29) Which of these protein combinations is found on an effector T cell, but not a naïve T cell?

 

Select one:

 

A.LFA-1 and CD40

 

 

 

B.VLA-4 and CD45RO

 

 

 

C.CD4 and TCR

 

 

 

D.VLA-4 and CD45RA

 

 

 

 

 

30)IgM’s pentameric structure makes it excellent at fixing complement through the classical pathway. What other antibody isotype is excellent at fixing complement due to its long hinge region?

 

Select one:

 

A.IgG2

 

 

 

B.IgG4

 

 

 

C.IgG3

 

 

 

D.IgG1

 

 

 

33)Somatic hypermutation is tested in centrocytes by their ability to acquire antigen from:

 

Select one:

 

A.Efferent lymph

 

 

 

B.FDCs

 

 

 

C.macrophages

D.Plasmacytoid dendritic cells