09 Oct RadioCHemistry Essay Assignment PaperRadioCHemistry Essay Assignment Paper

RadioCHemistry Essay Assignment Paper

Problems

4.1 Compute the amount of a radionuclide necessary to perform an experiment with a sample count rate of 1000 cpm, a detector efficiency of 33%, and a sample aliquot for counting consisting of 10% of the total isolated sample and where the percent incorporation of the nuclide into the total isolated sample was 0.5%.

 RadioCHemistry Essay Assignment Paper

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4.3 Three tracers, 90-year 151Sm (0.076 MeV β−, 100% of the disintegrations and 0.022 MeV X-ray, 4%), 244.3 days 65Zn (0.33 MeV β−, 1.7% of disintegrations and 0.511 MeV γ-rays, 3.45), and 14.3 days 32P (1.71 MeV β−, 100% of the disintegrations)will be used simultaneously in amulti-tracerProblems 111experiment. Suppose you wish to measure the uptake of these three elementsin the blood of a rat and the loss of these elements to the rest of therat’s organs and tissue from the blood. What levels of the tracer will youinject into the rat?Why? (Assume that you will withdraw 0.1 mL bloodvolumes every hour for 24 h. The total blood volume of an adult rat isabout 15 mL.)

 RadioCHemistry Essay Assignment Paper

4.5 Compound X, molecular weight of 150 (specific activity 1.0mCi/mmole), was checked for purity by carefully weighing 1.5 mgof the radiochemical, mixing with 1000 mg of unlabeled compound X,and recrystallizing until a constant specific activity. Radioassay gave avalue of 2500 dpm/mg. What was the purity of the radiochemical inpercent?

4.7 Consider two radiopharmaceuticals, A and B. Radiopharmaceutical Agenerates contrast in imaging by enhanced uptake in the organ of interestby uptake in this organ that is 10 times the uptake in the surroundingtissue. Radiopharmaceutical B generates contrast in imaging the sameorgan by reducing the uptake in the surrounding tissue by a factor of 10.Assume the organ to be imaged has a volume of 1 cm3, while the totaltissue affected has a volume of 10 cm3. Assume the background countingrate in the tissue is 10 cpm/cm3. Which is the better choice for imaging,A or B andwhy?

 RadioCHemistry Essay Assignment Paper

4.9 What is the accumulated activity in the liver if 50 MBq of 99Tcm isinjected in the body, assuming 50% is trapped by the liver and remainsthere? The accumulated activity is a measure of the total number ofdecays occurring in the organ during the time radioactivity is present inthe organ.112 Nuclear Medicine

4.11 A radionuclide decays by emitting 0.695 MeV β-particles. Its physical half-life is 14.5 days. Assume its biological half-life is 7.1 days. What isthe total energy deposited per kilogram in the body in one week fromthe absorption of 250 MBq? RadioCHemistry Essay Assignment Paper